The sulcal morphology of the human frontal lobe is highly variable. Although the structural images usually acquired in functional magnetic resonance imaging studies provide information about this interindividual variability, this information is only rarely used to relate structure and function. Here, we investigated the spatial relationship between posterior frontolateral activations in a taskswitching paradigm and the junction of the inferior frontal sulcus and the inferior precentral sulcus

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... nferior frontal junction, IFJ) on an individual-subject basis. Results show that, although variable in terms of stereotaxic coordinates, the posterior frontolateral activations observed in task-switching are consistently and reliably located at the IFJ in the brains of individual participants. The IFJ shares such consistent localization with other nonprimary areas as motion-sensitive area V5/MT and the frontal eye field. Building on tension-based models of morphogenesis, this structure-function correspondence might indicate that the cytoarchitectonic area underlying activations of the IFJ develops at early stages of cortical folding. Hum Brain Mapp 30:299-311, 2009. V V C 2007 Wiley-Liss, Inc. in Wiley InterScience (www. interscience.wiley.com). V V C 2007 Wiley-Liss, Inc. r Human Brain Mapping 30:299-311 (2009) r REFERENCES Aguirre GK, Zarahn E, D'Esposito M (1997): Empirical analyses of BOLD fMRI statistics. II. Spatially smoothed data collected under null-hypothesis and experimental conditions. Neuroimage 5(3):199-212. Amiez C, Kostopoulos P, Champod AS, Petrides M (2006): Local morphology predicts functional organization of the dorsal premotor region in the human brain. J Neurosci 26(10):2724-2731. Amunts K, von Cramon DY (2006): The anatomical segregation of the frontal cortex: What does it mean for function? Cortex 42(4):525-528. r Single-Subject IFJ Activations r r 309 r