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The role of RAS oncogenes in controlling epithelial mechanics
Mutations in RAS are key oncogenic drivers and therapeutic targets. Oncogenic Ras proteins activate a network of downstream signalling pathways, including extracellular signal-regulated kinase (ERK) and phosphatidylinositol 3-kinase (PI3K), promoting cell proliferation and survival. However, there is increasing evidence that RAS oncogenes also alter the mechanical properties of both individual malignant cells and transformed tissues. Here we discuss the role of oncogenic RAS in controllingdoi:10.1016/j.tcb.2022.09.002 pmid:36175301 pmcid:PMC9850021 fatcat:57jpynsnp5h4fozhxdnjntcc44