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Kynurenic acid (KYNA), tryptophan metabolite synthesized in the kynurenine pathway, is present in human body fluids as well as in variety of foods, herbal medicines and honeybee derived foodstuffs. KYNA is an endogenous antagonist of all ionotropic glutamate receptors. It has been found that glutamate antagonists inhibit proliferation of different human tumor cells. Quinaldic acid (QUINA), a derivative of KYNA, is also a tryptophan metabolite and shows high similarity to KYNA in physiologicaldoi:10.3390/proceedings1101045 fatcat:fzixjeluxbd6rp3ohd2f4h6zne