Aneuploidy in the embryonic progeny of females heterozygous for the Robertsonian chromosome (9.12) in genetically wild Peru--Coppock mice (Mus musculus)

M. J. Harris, M. E. Wallace, E. P. Evans
1986 Reproduction  
The spontaneous appearance of a Robertsonian translocation in a laboratory colony of genetically wild Peru\p=n-\Coppock mice gave the opportunity to study potential meiotic nondisjunction soon after the formation of the new chromosome and also in a hitherto untested combination of genotype and environment. Metaphase II scores from the progenitor male had indicated a nondisjunction rate of approximately 10%, a figure that was confirmed by the finding of an estimated 12\p=n-\16%total trisomic and
more » ... %total trisomic and probable monosomic zygotes in chromosomal studies of Day 9 embryos from heterozygous females. The chromosome studies also showed the presence of a significant excess of normal embryos that were heterozygous for the Robertsonian chromosome.
doi:10.1530/jrf.0.0760193 pmid:3944790 fatcat:4hzqqyftzne7nbudppzuqisvfi