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A susceptible-infected-susceptible (SIS) model of multiple contagions on multilayer networks is developed to incorporate different spreading channels and disease mutations. The basic reproduction number for this model is estimated analytically. In a special case when considering only compartmental models, we analytically analyze an example of a model with a mutation driven strain persistence characterized by the absence of an epidemic threshold. This model is not related to the network topologyarXiv:1703.02906v3 fatcat:oblvdakzbfgs5ku5ep7ivb7rg4