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Anthelmintic activity of nanoencapsulated carvacryl acetate against gastrointestinal nematodes of sheep and its toxicity in rodents

Weibson Paz Pinheiro André, José Ribamar de Paiva Junior, Géssica Soares Cavalcante, Wesley Lyeverton Correia Ribeiro, José Vilemar de Araújo Filho, Jéssica Maria Leite dos Santos, Ana Paula Negreiros Nunes Alves, Jomar Patrício Monteiro, Selene Maia de Morais, Isaac Neto Goes da Silva, Lorena Mayana Beserra de Oliveira, Flávia Oliveira Monteiro da Silva Abreu (+1 others)
2020 Revista Brasileira de Parasitologia Veterinária  

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The objective of this study was to evaluate the efficacy of carvacryl acetate (CVA) and nanoencapsulated CVA (nCVA) on gastrointestinal nematodes of sheep. The CVA was nanoencapsulated with chitosan/gum arabic and the efficacy of nanoencapsulation (EE), yield, zeta potential, nanoparticle morphology and release kinetics at pH 3 and 8 were analyzed. Acute and subchronic toxicity were evaluated in rodents and reduction of egg counts in the faeces (FECRT) of sheep. The sheep were divided into four
more » ... groups (n = 10): G1, 250 mg/kg CVA; G2, 250 mg/kg nCVA; G3, polymer matrix and G4: 2.5 mg/kg monepantel. EE and nCVA yield were 65% and 57%, respectively. The morphology of the nanoparticles was spherical, size (810.6±286.7 nm), zeta potential in pH 3.2 (+18.3 mV) and the 50% release of CVA at pHs 3 and 8 occurred at 200 and 10 h, respectively. nCVA showed LD50 of 2,609 mg/kg. CVA, nCVA and monepantel reduced the number of eggs per gram of faeces (epg) by 57.7%, 51.1% and 97.7%, respectively. The epg of sheep treated with CVA and nCVA did not differ from the negative control (P>0.05). Nanoencapsulation reduced the toxicity of CVA; however, nCVA and CVA presented similar results in the FECRT.
doi:10.1590/s1984-29612019098 pmid:32049139 fatcat:zwaq5fszyzai3go2a5dgt4xrou
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Weibson Paz Pinheiro André, José Ribamar de Paiva Junior, Géssica Soares Cavalcante, Wesley Lyeverton Correia Ribeiro, José Vilemar de Araújo Filho, Jéssica Maria Leite dos Santos, Ana Paula Negreiros Nunes Alves, Jomar Patrício Monteiro, Selene Maia de Morais, Isaac Neto Goes da Silva, Lorena Mayana Beserra de Oliveira, Flávia Oliveira Monteiro da Silva Abreu, Claudia Maria Leal Bevilaqua. "Anthelmintic activity of nanoencapsulated carvacryl acetate against gastrointestinal nematodes of sheep and its toxicity in rodents." Revista Brasileira de Parasitologia Veterinária 29.1 (2020) e013119