Optimization of diffusion imaging for multiple target regions using maximum likelihood estimation

Lars Bielak, Michael Bock
2017 Current Directions in Biomedical Engineering  
AbstractIn this work a procedure is proposed to determine an optimal distribution of b-values in diffusion MRI measu-rements. The optimization procedure uses a method of Maximum Likelihood Estimation which can operate on any given number of b-values, values of the diffusion coefficients (ADC) and measurement noise strengths. Optimal b-values are calculated for white and gray brain matter. An optimi-zation for more than one ADC is demonstrated using multiple target values.
doi:10.1515/cdbme-2017-0043 fatcat:3dzll2b5zze7bk67uc7djsaiaa