Prekallikrein Deficiency in a Dog

Takumi OKAWA, Takuma YANASE, Takako SHIMOKAWA MIYAMA, Hiroko HIRAOKA, Kenji BABA, Kenji TANI, Masaru OKUDA, Takuya MIZUNO
2011 Journal of Veterinary Medical Science  
Prekallikrein (PK) deficiency is an uncommon disorder in dogs. In this report, we describe a case of a dog that was referred for neurological defects and had a prolonged activated partial thromboplastin time (aPTT) and normal prothrombin time (PT) with no hemostatic defects. By using human PK-deficient plasma, the dog was diagnosed to have PK deficiency. The nucleotide sequence of normal canine PK cDNA was determined and compared with the genomic sequences of PK in the affected dog. The
more » ... on revealed that the dog had a point mutation in exon 8 that leads to an amino acid substitution in the fourth apple domain of PK. This is the first report showing a point mutation of PK in a dog with PK deficiency. KEY WORDS: canine, mutation, prekallikrein deficiency.
doi:10.1292/jvms.10-0207 pmid:20736516 fatcat:hzyyla6ufzh6phooobo7o4hywa