Synthesis of Calcium Phosphate Controllable Coating Thickness on Oil-in-Water Nanoemulsion with Performance of Oxygen Release as Oxygen Carrier

Kyu-Bum Han, Curtis Takagi, Chun-Jen Wu, Hiroshi Mizukami, Agnes Ostafin
2016 Journal of Biomaterials and Nanobiotechnology  
Perfluorocarbon emulsion has been studied as an oxygen carrier, due to its high oxygen content. In clinical trials, it has shown stability in delivering oxygen to the target region. The purpose of the present study was to increase the stability of the emulsion by coating its surface with calcium phosphate. A layer-by-layer method was employed to coat the flexible emulsion surface. Considering the ionic affinity of calcium and phosphate to the lecithin emulsion surface, the first layer of
more » ... rst layer of coating was calcium and the second layer was comprised of phosphate ion. The coated emulsion demonstrated various oxygen release times depending on the thickness of the layers: from 0.04 sec. for a thickness of 8 nm to 0.17 sec. for a thickness 38 nm. Overall, the stability of the calcium phosphate coated emulsion was increased, while its original function as an oxygen carrier was maintained.
doi:10.4236/jbnb.2016.72007 fatcat:24cvk3irm5ebva3auovjnqlyz4