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Blood Cancer Journal
Dear Editor, Acute myeloid leukemia (AML) patients carrying complex karyotype or aneuploidies have a very poor prognosis, with a 5-year overall survival (OS) <20% 1 . We and others have shown that these patients are characterized by high genomic instability, along with defects of DNA damage response (DDR) genes 2,3 . Partner and localizer of BRCA2 (PALB2) is a key player in the homology recombination (HR) pathway, since it functions as a scaffold for the HR complex 4 . PALB2 monoallelicdoi:10.1038/s41408-020-00396-x pmid:33414401 fatcat:s6c2mtutqrev3idqqabquu2aee