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It is known that water deprivation or injection of hypertonic saline induces anorexia. The present study examined the possible involvement of vasopressin in the suppression of food intake during high plasma osmolality. Intraperitoneal injection of vasopr essin (20 µg/kg) into male rats significantly suppressed food intake for 1 hr. This anorectic effect of vasopressin was reversed by simultaneous injection of a peptide antagonist for V 1 receptor (40 µg/kg), but not for V 2 receptor (40 µg/kg).doi:10.1292/jvms.66.951 pmid:15353846 fatcat:rwnbk2n6jzcxvlembyw342qbg4