Synthesis, Antimicrobial, and Antioxidant Activities of N-[(5′-Substituted-2′-phenyl-1H-indol-3′-yl)methylene]-5H-dibenzo[b,f]azepine-5-carbohydrazide Derivatives

Anand R. Saundane, Vijaykumar Tukaram Katkar, A. Verma Vaijinath
2013 Journal of Chemistry  
The main aim of the present study was to synthesize new leads with potential antimicrobial and antioxidant activities. As a part of systematic investigation of synthesis and biological activity, some new indole compounds3a–cand4a–cwere prepared and screened for their antimicrobial and antioxidant activities. The antimicrobial evaluation of newly synthesized compounds was carried out by cup-plate method. Antimicrobial activity results revealed that compound4ashowed promising activity against
more » ... ctivity against bacteriaStaphylococcus aureus,Klebsiella pneumonia, andPseudomonas aeruginosaand exhibited maximum inhibition againstAspergillus niger,Aspergillus oryzae,Aspergillus terreus, andAspergillus flavus. The antioxidant activity was performed by three methods, namely, radical scavenging activity (RSA), ferric ions (Fe+3) reducing antioxidant power (FRAP), and metal chelating activity by using Hatano's, Oyaizu's, and Dinis' methods, respectively. Compound4ashowed promising RSA, FRAP, and metal chelating activity.
doi:10.1155/2013/530135 fatcat:ezmhp7riv5gbdfg3oyefpaxnsy