Atividade antibacteriana de floroglucinóis e do extrato hexânico de Hypericum brasiliense Choysi

Hildegardo Seibert França, Ricardo Machado Kuster, Priscila da Nóbrega Rito, Adriana Passos de Oliveira, Lenise Arneiro Teixeira, Leandro Rocha
2009 Química Nova  
Recebido em 10/10/07; aceito em 11/12/08; publicado na web em 28/4/09 ANTIBACTERIAL ACTIVITY OF THE PHLOROGLUCINOLS AND HEXANIC EXTRACT FROM Hypericum brasiliense Choysi. Three phloroglucinols were obtained from Hypericum brasiliense: japonicine A (1), isouliginosin B (2) and uliginosin B (3). Bioautography and disk diffusion methods were used to determine antibacterial activity of the hexanic extract. Strains of the Coagulase Negative Staphylococcus and American Methicillin Resistant
more » ... Resistant Staphylococcus aureus clones showed a growth inhibition zone ranging from 10 to 12 mm and 7 to 15 mm, respectively. Minimal inhibitory concentration (MIC) values were used to measure antistaphylococcal activity for all phloroglucinols. Isouliginosin B and uliginosin B presented MIC values of 1.5 and 3.0 µg/mL, respectively, while japonicine A displayed MIC value of 50.0 µg/mL.
doi:10.1590/s0100-40422009000500004 fatcat:2bph3xrqlrhnfe5owcue5c7q2i