Age related macular degeneration: A study of patients managed with radiotherapy

Anusheel Munshi, Rajiv Sarin, Ajay Dudhani, KetayunA Dinshaw
2007 Journal of Cancer Research and Therapeutics  
f o r f r e e d o w n l o a d f r o m a s i t e h o s t e d b y M e d k n o w P u b l i c a t i o n s ( w w w . m e d k n o w . c o m ) . ABSTRACT Rajiv Sarin, Introduction: Age-related macular degeneration (ARMD) is the leading cause of blindness in the west. Radiotherapy affects the Ajay Dudhani*, Ketayun A Dinshaw evolution of exudative macular degeneration directly by its effect on the endothelium and inflammation modulation. We conducted a retrospective study to evaluate the improvement in
more » ... the improvement in visual acuity and healing of sub retinal neovascular membrane (SRNV) following Department of Radiation fractionated radiotherapy. Oncology, Tata Memorial Materials and Methods: 47 patients (58 eyes) of ARMD were retrospectively analyzed. One of the following radiotherapy Center, Mumbai, India fractionation schedules was employed in all the patients in this study. a) 15 Gy /5 fractions/1 week (five patients) b) 20 Gy/5 fractions/ For correspondence: 1 week (19 patients) c) 22.5Gy/5 fractions/1 week (21 patients) d) 25 Gy/5 fractions/1 week (two patients). VA and funduscopy was Dr. Anusheel Munshi, taken at each follow-up for objective improvement and to assess the healing of SRNV. Department of Radiation Oncology, Tata Memorial Results: The median follow-up was 7.23 months. The mean improvement in the VA in the entire group was of 0.44 line. (Median 1, Hospital, Parel, Mumbai, SD 1.04). Overall 75% of the eyes showed either steady vision or an improvement in subjective vision analysis. The deterioration free survival was significantly better in the group that had a relatively short duration of symptoms (P=0.01). Scarring at presentation was a significant adverse factor for improvement in vision after radiotherapy (P= 0.001). anusheel8@ Conclusions: In patients of ARMD treated with radiotherapy, the initial duration of symptoms and scarring of eyes at presentation were significant prognostic variables for improvement in VA after radiotherapy.
doi:10.4103/0973-1482.31965 pmid:17998713 fatcat:u2m4ij2lu5bwjnsegi7mjtoszm