Age related macular degeneration: A study of patients managed with radiotherapy
Journal of Cancer Research and Therapeutics
f o r f r e e d o w n l o a d f r o m a s i t e h o s t e d b y M e d k n o w P u b l i c a t i o n s ( w w w . m e d k n o w . c o m ) . ABSTRACT Rajiv Sarin, Introduction: Age-related macular degeneration (ARMD) is the leading cause of blindness in the west. Radiotherapy affects the Ajay Dudhani*, Ketayun A Dinshaw evolution of exudative macular degeneration directly by its effect on the endothelium and inflammation modulation. We conducted a retrospective study to evaluate the improvement in
... the improvement in visual acuity and healing of sub retinal neovascular membrane (SRNV) following Department of Radiation fractionated radiotherapy. Oncology, Tata Memorial Materials and Methods: 47 patients (58 eyes) of ARMD were retrospectively analyzed. One of the following radiotherapy Center, Mumbai, India fractionation schedules was employed in all the patients in this study. a) 15 Gy /5 fractions/1 week (five patients) b) 20 Gy/5 fractions/ For correspondence: 1 week (19 patients) c) 22.5Gy/5 fractions/1 week (21 patients) d) 25 Gy/5 fractions/1 week (two patients). VA and funduscopy was Dr. Anusheel Munshi, taken at each follow-up for objective improvement and to assess the healing of SRNV. Department of Radiation Oncology, Tata Memorial Results: The median follow-up was 7.23 months. The mean improvement in the VA in the entire group was of 0.44 line. (Median 1, Hospital, Parel, Mumbai, SD 1.04). Overall 75% of the eyes showed either steady vision or an improvement in subjective vision analysis. The deterioration free survival was significantly better in the group that had a relatively short duration of symptoms (P=0.01). Scarring at presentation was a significant adverse factor for improvement in vision after radiotherapy (P= 0.001). anusheel8@ hotmail.com Conclusions: In patients of ARMD treated with radiotherapy, the initial duration of symptoms and scarring of eyes at presentation were significant prognostic variables for improvement in VA after radiotherapy.