Optimization and sustainability assessment of a continuous flow Ru-catalyzed ester hydrogenation for an important precursor of a β2-adrenergic receptor agonist

Michael Prieschl, Jorge García-Lacuna, Rachel H. Munday, Kevin Leslie, Anne O'Kearney McMullan, Christopher A Hone, C. Oliver Kappe
2020 Green Chemistry  
The development of a ruthenium-catalyzed continuous flow ester hydrogenation using hydrogen (H2) gas is reported. The reaction was utilized for the reduction of an important precursor in the synthesis of...
doi:10.1039/d0gc02225j fatcat:37g3dqh3xzghplfuqvressx2ne