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Persistent and uncontrolled use of antibiotics results in development of bacterial resistant. The situation is getting worsen day by day and scientists are investigating thousands of potentially active drugs like molecule in laboratories around the world every day in search of effective antibiotics. During last decade considerable attention was given to five-member heterocyclic moieties while designing new antimicrobial agents. One of important heterocycle is five-membered 1,3,4-thiadiazoledoi:10.9734/jpri/2021/v33i62a35203 fatcat:4vb3ykzgpve6dgzcp7ifu3dkva