Exhaled Breath Condensate for Proteomic Biomarker Discovery

Sean Harshman, Claude Grigsby, Darrin Ott
2014 Chromatography  
Exhaled breath condensate (EBC) has been established as a potential source of respiratory biomarkers. Compared to the numerous small molecules identified, the protein content of EBC has remained relatively unstudied due to the methodological and technical difficulties surrounding EBC analysis. In this review, we discuss the proteins identified in EBC, by mass spectrometry, focusing on the significance of those proteins identified. We will also review the limitations surrounding mass spectral
more » ... ng mass spectral EBC protein analysis emphasizing recommendations to enhance EBC protein identifications by mass spectrometry. Finally, we will provide insight into the future directions of the EBC proteomics field.
doi:10.3390/chromatography1030108 fatcat:cuuacm57v5g4lan5os6wels2km