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BCG Moreau Rio de Janeiro: an oral vaccine against tuberculosis - review
2005
Memórias do Instituto Oswaldo Cruz
The vaccine Bacillus of Calmette Guérin (BCG) was originally developed in France as an oral vaccine against tuberculosis. The oral use of this vaccine was replaced by the parenteral route in almost all countries after the Lubeck disaster. In contrast, Brazil retained the oral delivery of the vaccine until the mid-seventies when it was replaced by the intradermal route. This change in route of delivery was mainly secondary to pressure by medical practitioners based on the poor responses of oral
doi:10.1590/s0074-02762005000500002
pmid:16184220
fatcat:t6mgpffoybe7zlpv5o7mfua5gq