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Altered splicing associated with the pathology of inflammatory bowel disease
2021
Human Genomics
Background Aberrant splicing of individual genes is a well-known mechanism promoting pathology for a wide range of conditions, but disease is less commonly attributed to global disruption of exon usage. To explore the possible association of aberrant splicing with inflammatory bowel disease, we developed a pipeline for quantifying transcript abundance and exon inclusion transcriptome-wide and applied it to a dataset of ileal and rectal biopsies, both obtained in duplicate from 34 pediatric or
doi:10.1186/s40246-021-00347-y
pmid:34301333
pmcid:PMC8305504
fatcat:t6tlx4cnazfbpjtqtj6rzw5zb4