Over-expression of tissue specific transplantation antigen P35B in human endometrial cancer [post]

Shahan Mamoor
2021 unpublished
Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified tissue specific transplantation antigen P35B, encoded by TSTA3, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. TSTA3 was expressed at significantly higher
more » ... ficantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of TSTA3 was correlated with recurrence-free survival in white patients with low mutational burden. TSTA3 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.
doi:10.31219/osf.io/84bau fatcat:pcgocq3dpzfjpcuafknland4qq