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We present performance results on a Windows cluster with up to 768 cores using MPI and two variants of threading -CCR and TPL. CCR (Concurrency and Coordination Runtime) presents a message based interface while TPL (Task Parallel Library) allows for loops to be automatically parallelized. MPI is used between the cluster nodes (up to 32) and either threading or MPI for parallelism on the 24 cores of each node. We look at performance of two significant bioinformatics applications; gene clusteringdoi:10.1109/ccgrid.2010.105 dblp:conf/ccgrid/QiuBBEF10 fatcat:uw5utdknnjdydfeffaxmx5qfaq