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Pharmacological inhibition of thioredoxin reductase increases insulin secretion and diminishes beta cell viability
2021
Naunyn-Schmiedeberg's Archives of Pharmacology
Apparently, both a decrease in beta cell function and in beta cell mass contribute to the progressive worsening of type 2 diabetes. So, it is of particular interest to define factors which are relevant for the regulation of insulin secretion and at the same time for the maintenance of beta cell mass. The NADPH-thioredoxin system has a candidate role for such a dual function. Here, we have characterized the effects of a highly specific inhibitor of thioredoxin reductase, AM12, on the viability
doi:10.1007/s00210-020-02046-2
pmid:33464387
pmcid:PMC8208932
fatcat:rhchhokvw5byrhiyowbfedmeo4