The function and morphology of Endothelial Cells (ECs) play a key role in atherosclerosis. The mechanical stimuli of ECs, such as Wall Shear Stress (WSS) and arterial wall strain, greatly in uence the function and morphology of these cells. The present article deals with computations of these stimuli for a 3D model of a healthy coronary artery bifurcation. The focus of the study is to propose an accurate method for computations of WSS and strains. Two approaches are considered: Coupled

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... ous simulation of arterial wall and blood ow, called Fluid-Structure Interaction (FSI) simulation, and decoupled, which simulates each domain ( uid and solid domain) separately. The study demonstrates that the computed circumferential strains resulting from both methods are identical. However, longitudinal strain and WSS are very di erent from these two approaches. The resulting Time Averaged Wall Shear Stress (TAWSS) from the decoupled uid model is always higher than the corresponding value from FSI simulation, while the Oscillatory Shear Index (OSI) from the rigid wall model is lower than the values resulting from FSI. Therefore, the decoupled simulation may underestimate the atheroprone sites of the artery, which suggests that using FSI simulation for mechanical stimuli of ECs is inevitable.