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Is MAC the knife that cuts cytochrome c from mitochondria during apoptosis?
Cell Death and Differentiation
Apoptosis is a phenomenon fundamental to higher eukaryotes and essential to mechanisms controlling tissue homeostasis. Bcl-2 family proteins tightly control this cell death program by regulating the permeabilization of the mitochondrial outer membrane and, hence, the release of cytochrome c and other proapoptotic factors. Mitochondrial apoptosisinduced channel (MAC) is the mitochondrial apoptosisinduced channel and is responsible for cytochrome c release early in apoptosis. MAC activity isdoi:10.1038/sj.cdd.4401949 pmid:16676005 fatcat:mg4m24bh6bejbasbinus55qjgq