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Instrumental variable methods in comparative safety and effectiveness research
Instrumental variable (IV) methods have been proposed as a potential approach to the common problem of uncontrolled confounding in comparative studies of medical interventions, but IV methods are unfamiliar to many researchers. The goal of this article is to provide a non-technical, practical introduction to IV methods for comparative safety and effectiveness research. We outline the principles and basic assumptions necessary for valid IV estimation, discuss how to interpret the results of andoi:10.17615/s8vm-tp28 fatcat:4fz7dkne5jgrvk2fq7aqz6enru