The young brain and concussion: Imaging as a biomarker for diagnosis and prognosis

Esteban Toledo, Alyssa Lebel, Lino Becerra, Anna Minster, Clas Linnman, Nasim Maleki, David W. Dodick, David Borsook
2012 Neuroscience and Biobehavioral Reviews  
Concussion (mild traumatic brain injury (mTBI)) is a significant pediatric public health concern. Despite increased awareness, a comprehensive understanding of the acute and chronic effects of concussion on central nervous system structure and function remains incomplete. Here we review the definition, epidemiology, and sequelae of concussion within the developing brain, during childhood and adolescence, with current data derived from studies of pathophysiology and neuroimaging. These findings
more » ... ay contribute to a better understanding of the neurological consequences of traumatic brain injuries, which in turn, may lead to the development of brain biomarkers to improve identification, management and prognosis of pediatric patients suffering from concussion.
doi:10.1016/j.neubiorev.2012.03.007 pmid:22476089 pmcid:PMC3372677 fatcat:eqnw7g2klzcizaegi5m5ox4giu