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Enhancers are powerful and versatile agents of cell-type specific gene regulation, which are thought to play key roles in human disease. Enhancers are short DNA elements that function primarily as clusters of transcription factor binding sites that are spatially coordinated to regulate expression of one or more specific target genes. These regulatory connections between enhancers and target genes can therefore be characterized as enhancer-gene links that can affect development, disease, anddoi:10.1371/journal.pone.0243791 pmid:33320871 pmcid:PMC7737992 fatcat:b47f767tsndzfkp7eparerw5oe