The Effect of a Single Mega dose Injection of Vitamin D on serum Adiponectin concentration at First Gestational Diabetes Mellitus: A Randomized Controlled Clinical Trial [post]

2019 unpublished
vitamin D is being increasingly recognized for its important non-skeletal functions including endocrine actions. This study investigated if a single, large, intramuscular post-artum injection of vitamin D improve adiponectin levels among women with gestational diabetes mellitus (GDM). Methods: A total of 45 pregnant women with GDM participated in this randomized clinical trial. They were randomly divided into intervention and control group. The intervention group received an intramuscular
more » ... intramuscular injection of 300,000 IU of vitamin D during 3 to 10 days after their child delivery, but controls did not. Serum 25-hydroxyvitamin D, fasting blood glucose, HbA1c and serum adiponectin were measured at baseline and after 3 months of intervention. Results: Serum 25 OH vitamin D increase significantly in the intervention but not in the control group from 24.25 to 62.10 (nmol/l) (p-value< 0.01). Comparison in within group showed that adiponectin level increased significantly only among intervention group after the vitamin D injection from 7.45 to 8.98 (ngr/dl) (P-value=0.01), while between group comparisons showed no significant differences in adiponectin concentration after the intervention (P-value<0.05). Between and within group comparisons reported no significant alterations in the levels of glycated hemoglobin (HbA1c) and FPG (fasting plasma glucose), as well. Conclusions: The 300,000 IU single dose of intramuscular injection of vitamin D is regarded as an effective procedure to improve vitamin D status which significantly increased the adiponectin levels among mothers with gestational diabetes after delivery. Trial registration: The trial was registered in Iranian Registry of Clinical Trials available at The reference number is IRCT138902113840N1. Background Vitamin D has been widely confirmed to improve the bone mineralization and calcium homeostasis [1]; Though, apart from this traditional role, vitamin D is being increasingly recognized for its important non-skeletal functions including endocrine and physiological actions (2) since it is mediated through vitamin D receptor (VDR) which is widely expressed in many related tissues, such as adipocytes, smooth muscles, skin, immune system, colon, pancreatic β-cells, keratinocytes, osteoblasts and vasculature tissues (3). In a multinational study, the prevalence of vitamin D
doi:10.21203/rs.2.13094/v1 fatcat:wcfpazuscjdx5nhezcpozc2e44