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Chest LDCT provides an effective approach for lung cancer screening, yet has been found to generate a large number of false positives during practice due to excessive diagnosis of pulmonary lesions of indeterminate clinical significance. In this study, we performed comprehensive genetic and epigenetic profiling of cfDNA from lung cancer patients and individuals bearing benign lung lesions, using ultra-deep targeted sequencing and targeted bisulfite sequencing. We found that cfDNA mutationdoi:10.1101/2020.08.20.20179044 fatcat:bdbyqiezhrbyze7zxiusvjiqlu