Formulation and Characterization of Gastroretentive Floating Tablets of Atorvastatin Calcium Using Central Composite Design

Beena Kumari, Parijat Pandey, Harish Dureja
2017 Journal of Pharmaceutical Research  
The aim of the study was to develop a gastroretentive floating drug delivery system of atorvastatin calcium by effervescence technique. Design/methodology/approach: The objective behind the study was to investigate the effect of concentration of HPMC K4M (X ), concentration of guar gum (X ), concentration of sodium bicarbonate (X ) on the release of 1 2 3 atorvastatin calcium using central composite design.The floating tablets were formulated using atorvastatin calcium (20% w/w), HPMC K4M
more » ... /w), HPMC K4M (5-15% w/w), guar gum (5-15% w/w), sodium bicarbonate (4-12% w/w), lactose (q.s.), talc (2% w/w) and magnesium stearate (1% w/w). Atorvastatin calcium floating tablets were evaluated for physical characterization viz. hardness, swelling index, floating capacity, weight variation, friability, in vitro drug release and kinetic studies. Findings: All tablets were floated for more than 12 hrs in 0.1 N HCl at 37±0.5°C and the in vitro drug release was found to be vary from 79% to 93%. The percentage cumulative drug released was maximum at low value of HPMC, low value of guar gum and high value of sodium bicarbonate. A mathematical model was developed to formulate floating tablets of atorvastatin calcium. The data fitting to Korsemeyer-Peppas equation revealed that the release mechanism from the dosage form followed the non-fickian transport. Value: The gastroretentive floating tablets of atorvastatin calcium will enhance the patient compliance and play a vital role in improving patient's quality of life.
doi:10.18579/jpcrkc/2017/16/3/118782 fatcat:4kzulvaxvbgftev66v5jlnp2ju