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AACR Education book
Genome instability and transcriptome aberrations are hallmark of cancers. Th e heterogeneities of cancer genomes demand large scale, whole genome and low cost approaches that allow comprehensive characterization of oncogenomes at fi ne resolution. Inspired by the recent revolution of DNA sequencing technology, we have developed a pair-endditag (PET) sequencing strategy for genome annotation and structural characterization. By extracting paired end signatures from desired DNA fragments anddoi:10.1158/aacr.edb-08-8437 fatcat:tarwmyo64bblhpgzo2sfmipfke