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PURPOSE: The human hand plays an essential role in our normal daily activities. The anatomical complexity of the hand, and critical functions of each of its component tissues, highlights the need to understand and effectively treat injuries to this vital multi-tissue structure. Surgical repair is often complicated by the scarcity of local soft tissue and loss of functional capacity. Reports of "salamander-like" spontaneous regeneration in human fingertips and recent advances using mouse modelsdoi:10.1097/01.gox.0000558364.46412.ee fatcat:l65d5gpkhrbxphkzvdks6xvsie