Abstract 90

David Foulad, Xiaoyan Ren, Qi Zhou, Marley Dewey, Brendan Harley, Justine C. Lee
2019 Plastic and Reconstructive Surgery, Global Open  
PURPOSE: The human hand plays an essential role in our normal daily activities. The anatomical complexity of the hand, and critical functions of each of its component tissues, highlights the need to understand and effectively treat injuries to this vital multi-tissue structure. Surgical repair is often complicated by the scarcity of local soft tissue and loss of functional capacity. Reports of "salamander-like" spontaneous regeneration in human fingertips and recent advances using mouse models
more » ... using mouse models of digit tip regeneration raise the possibility of restorative/regenerative rather than reparative approaches for traumatic hand injuries. These mouse studies demonstrate the various embryonic origins of mammalian limb tissue, including ectoderm, mesoderm, and neural crest, the role of lineage-restricted stem and progenitor cells in mammalian digit regeneration and some of the signaling pathways involved. The discrete signaling mechanisms governing this regenerative process, however, remain poorly understood.
doi:10.1097/01.gox.0000558364.46412.ee fatcat:l65d5gpkhrbxphkzvdks6xvsie