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Studies on nonprecipitating insulin antibody. Radioimmunoassay of insulin binding capacity and its relationship to insulin neutralizing activity and ability to evoke cutaneous anaphylactic reaction
Nagoya journal of medical science
Skom and Talmage have demonstrated a non-precipitating antibody against insulin in the sera of insulin-treated diabetics. But their m ethod of determining the antibody is not quantitative. In the present study, a titration of the insulin binding activity of anti-insulin was performed more quantitatively using 13 11-labeled insulin and a ntiguinea pig r-globulin rabbit sera under the condition of insulin excess.-Moreover, the insulin binding act ivity of anti-insulin was corr elated with itspmid:5704920 fatcat:sp57ysympnerxgwwwq5za3sbyu