Primary Signet Ring Cell Carcinoma of Prostate- A Rare Occurrence

Iffat Jamal
2019 Journal of Evidence Based Medicine and Healthcare  
A BS T R A C T BACKGROUND Primary signet ring cell carcinoma of prostate is an extremely rare variant of prostatic adenocarcinoma having a grave prognosis. It is characterized by an intracytoplasmic vacuole compressing the nucleus into a crescent shape at the cellular level. Although SRCC is primarily found in the stomach and colon, it can also be found in the pancreas, breast, thyroid, bladder, and prostate. Establishing a diagnosis of SRCC of the prostate requires histopathologic examination
more » ... ologic examination of the tissue, a negative gastrointestinal (GI) work-up (including computed tomography of the abdomen, a colonoscopy, and an esophagogastroduodenoscopy), and various stains. A PubMed based literature search was made regarding the incidence, clinical manifestations, microscopy, histological grade and stage of this tumour. Signet ring cell carcinoma, a rare and aggressive subtype of adenocarcinoma of the prostate, requires careful diagnosis via thorough evaluation and specialized staining processes. Although the rarity of this disease does not allow for the establishment of absolute recommendations, treatment is often similar to traditional radical management of cancer of the prostate, with emphasis on an aggressive multimodal approach. Patients with SRCC of the prostate have an ominous prognosis and should be treated aggressively and followed up closely. Primary signet ring cell carcinoma is a rare variant of adenocarcinoma and therefore a detailed clinico-radiological and pathological work up should be done in order to rule out primary from other common sites.
doi:10.18410/jebmh/2019/660 fatcat:uruhmpcu3bdv5fi7e6kvc2hs7u