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The human ABO(H) blood group phenotypes arise from the evolutionarily oldest genetic system found in primate populations, but they originated in critical molecular complementarity with distinct eukaryotic and prokaryotic pathogens, while the development of non-O(H) phenotypes is associated with impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotype formation in plasma proteins. Indeed, compared with individuals with blood group O(H), blooddoi:10.6084/m9.figshare.4714618.v304 fatcat:2tjz3p4opreptdqy5tyq6x267i