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Background: Nosema bombycis is a unicellular eukaryotic pathogen of the silkworm, Bombyx mori, and a hazard to the silkworm industry. Because of its long incubation period and horizontal and vertical transmission, it is a quarantine pathogen in sericulture. The microsporidian life cycle includes a dormant extracellular phase and intracellular proliferation phase. The proliferation period is the most active period of the microsporidian. This period lacks spore wall protection and may be the mostdoi:10.21203/rs.3.rs-117766/v1 fatcat:yrs4mufnejduhfsjz6bogjdkye