Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis

Vanessa Chapla, Maria Zeraik, Valdecir Ximenes, Lisinéia Zanardi, Márcia Lopes, Alberto Cavalheiro, Dulce Silva, Maria Young, Luiz Fonseca, Vanderlan Bolzani, Angela Araújo
2014 Molecules  
Chemical investigation of an acetonitrile fraction from the endophytic fungus Phomopsis sp. led to the isolation of the new natural product 2-hydroxy-alternariol (7) together with the known compounds cytochalasins J (1) and H (2), 5'-epialtenuene (3) and the mycotoxins alternariol monomethyl ether (AME, 4), alternariol (AOH, 5) and cytosporone C (6). The structure of the new compound was elucidated by using 1-D and 2-D NMR (nuclear magnetic resonance) and high resolution mass spectrometry. The
more » ... spectrometry. The cytochalasins J (1) and H (2) and AOH (5) exhibited potent inhibition of the total ROS (reactive oxygen species) produced by stimulated human neutrophils and acted as potent potential anti-inflammatory agents. Moreover, cytochalasin H (2) demonstrated antifungal and acetylcholinesterase enzyme (AChE) inhibition in vitro.
doi:10.3390/molecules19056597 pmid:24858094 fatcat:2p7v2vuaanb7fkwjiionqj7edu