Genome wide association test to identity QTL for dressing percentage in Hanwoo
전장 유전체 관련성 분석을 통한 한우 도체수율 관련 양적형질좌위 탐색

Seung Hwan Lee, Dajeong Lim, Chang Gwan Dang, Sun Sik Chang, Hyeong Cheul Kim, Gi Jun Jeon, Seong Hum Yeon, Gul Won Jang, Eung Woo Park, Jae Don Oh, Hak Kyo Lee, Jun Heon Lee (+2 others)
2013 Korean Journal of Agricultural Science  
Genome-wide association study was performed on data from 266 Hanwoo steers derived from 66 sire using bovine 10K mapping chip in Hanwoo (Korean Cattle). SNPs were excluded from the analysis if they failed in over 5% of the genotypes, had median GC scores below 0.6, had GC scores under 0.6 in less than 90% of the samples, deviated in heterozygosity more than 3 standard deviations from the other SNPs and were out of Hardy-Weinberg equilibrium for a cutoff p-value of 1 -15 . Unmapped and SNPs on
more » ... apped and SNPs on sex chromosomes were also excluded. A total of 4,522 SNPs were included in the analysis. To test an association between SNP and QTL, GWAS for five genetic mode (additive, dominant, overdominant, recessive and codominant) was implemented in this study. Three SNPs (rs29018694, ss46526851 and rs29018222) at a threshold p<1.11×10 -5 were detected on BTA12 and BTA21 for dressing percentages in codominant and recessive genetic mode. The G allele for rs29018694 has 4.9% higher dressing percentage than A allele, while the T allele for ss46526851 has 2.57 % higher dressing percentage than C allele. Therefore, rs29018694 SNP showed a bigger effect than the other two SNPs (ss46526851 and rs29018222) in this study. In conclusion, this study identifies three loci with moderate effects and many loci with infinitesimally small effect across genome in Hanwoo.
doi:10.7744/cnujas.2013.40.2.155 fatcat:psbzq7js5fgpleddmfinxjeczu