An unusual case of IgA-dominant postinfectious glomerulonephritis: a case report and review of the literature

Małgorzata Wagrowska-Danilewicz, Marian Danilewicz, Iwona Fisiak, Joanna Piskorska
2016 Polish Journal of Pathology  
We report a case of IgA-dominant postinfectious glomerulonephritis in a 49-yearold man presenting with acute kidney injury, nephrotic range proteinuria and hematuria. He suffered from ischemic heart disease, cardiac insufficiency, mitral regurgitation, tricuspid insufficiency, septal aneurysm and hypertension. Renal biopsy revealed segmental and focal endocapillary and mesangial hypercellularity, and thickening of the glomerular capillary wall. Immunofluorescence showed co-dominant strong
more » ... granular immunostaining of IgA, IgG and C3 mainly along the glomerular capillary wall. On electron microscopy some large subepithelial hump-shaped deposits were present. In summary, this case demonstrates the presence of a broad spectrum of glomerular histological findings in postinfectious glomerulonephritis.
doi:10.5114/pjp.2016.61455 fatcat:nhqait7v6jhizbkoi3vfvknlo4