Defining pathogenic verocytotoxin-producing Escherichia coli (VTEC) from cases of human infection in the European Union, 2007–2010

W. MESSENS, D. BOLTON, G. FRANKEL, E. LIEBANA, J. McLAUCHLIN, S. MORABITO, E. OSWALD, E. J. THRELFALL
2014 Epidemiology and Infection  
SUMMARYDuring 2007–2010, 13 545 confirmed human verocytotoxin (VT)-producingEscherichia coli(VTEC) infections were reported in the European Union, including 777 haemolytic uraemic syndrome (HUS) cases. Clinical manifestations were reported for 53% of cases, 64% of which presented with diarrhoea alone and 10% with HUS. Isolates from 85% of cases were not fully serotyped and could not be classified on the basis of the Karmali seropathotype concept. There is no single or combination of phenotypic
more » ... tion of phenotypic or genetic marker(s) that fully define 'pathogenic' VTEC. Isolates which contain thevtx2(verocytotoxin 2) gene in combination with theeae(intimin-encoding) gene oraaiC(secreted protein of enteroaggregativeE. coli) andaggR(plasmid-encoded regulator) genes have been associated with a higher risk of more severe illness. A molecular approach targeting genes encoding VT and other virulence determinants is thus proposed to allow an assessment of the potential severity of disease that may be associated with a given VTEC isolate.
doi:10.1017/s095026881400137x pmid:25921781 fatcat:ao2p4syqafgdhojajixlgqochy