Synthesis and characterization of zein-chromium nanoparticles with antibacterial effects

AHMED KAREEM HAMMOOD JABERI, Faculty of Biology, University of Bucharest, Splaiul Independentei, No 91-95, 050095, Bucharest, Romania, ERIKA COPACI, MARIA MERNEA, RAWAA SHAKIR SHANAIN AL-SHAMMARI, LUDMILA OTILIA CINTEZA, DAN FLORIN MIHAILESCU, GHEORGHE STOIAN
2020 Romanian Biotechnological Letters  
Antibiotic resistance is a major problem of modern medicine. Due to the ability of Gram-negative bacteria to develop resistance against antibiotics, novel therapeutic strategies are emerging based on nanomaterials that perform a controlled release of antibacterial agents that don't promote resistance. Protein nanoparticles are good candidates for this approach because they are biocompatible, biodegradable and non-toxic. Zein is a protein from corn that is able to assemble into nanoparticles.
more » ... o nanoparticles. Zein nanoparticles loaded with essential oils, plant extracts or with silver nanoparticles presented a good stability and superior antibacterial effects. Taking into account that trivalent chromium ions (Cr 3+ ) conjugated with amino acids have antibacterial and antifungal activity, here we have synthesized and tested the antibacterial effect of zein nanoparticles loaded with Cr 3+ against two E. coli strains with different antibiotic resistance profiles. The nanoparticles that we synthesized are 20-50 nm in size. While zein nanoparticles without Cr 3+ have no antibacterial effect, chromium-zein nanoparticles inhibit the growth of the two strains and the biofilm formation. Given the effectiveness of chromium-zein nanoparticles against bacterial strains with resistance to different classes of antibiotics and the advantages offered by zein, these are good candidates for diverse biomedical applications.
doi:10.25083/rbl/25.3/1628.1634 fatcat:l6fzis7fr5h3xfrx4mqenl3jiy