Successful Treatment of Acute Chest Syndrome with Manual Exchange Transfusion in a Patient with Sickle Beta+-thalassemia

Akihiro Kawahara, Takehiko Morioka, Yuichiro Otani, Keishi Kanno, Taro Edahiro, Noriyasu Fukushima, Sachi Nagasaka, Mika Housai, Masaki Kakimoto, Naoki Tsuji, Shuntaro Asano, Yuka Kikuchi (+8 others)
2019 Internal medicine (Tokyo. 1992)  
Acute chest syndrome (ACS), characterized by fever, respiratory symptoms, and new pulmonary infiltration, is a serious complication of sickle cell disease (SCD). Regardless of the etiology, the conventional treatment options for ACS include empirical antibiotic therapy, the administration of analgesics, and red cell transfusion. The indications and methods of red cell transfusion are critical. We herein report the case of a 26-year-old African-American man with SCD who developed ACS and who was
more » ... ped ACS and who was successfully treated with manual exchange transfusion. Despite increasing globalization, SCD remains extremely rare in Japan. Manual exchange transfusion can be performed easily anywhere and should be considered for treating SCD patients presenting with ACS.
doi:10.2169/internalmedicine.1753-18 fatcat:3ng6b2kfyre3naf3yossguxi5q