Identification of novel cyclin gene fusion transcripts in endometrioid ovarian carcinomas

Antonio Agostini, Marta Brunetti, Ben Davidson, Claes Göran Tropé, Sverre Heim, Ioannis Panagopoulos, Francesca Micci
<span title="2018-04-25">2018</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="" style="color: black;">International Journal of Cancer</a> </i> &nbsp;
3 Cover Illustration Bellerophon fighting the Chimera, Roman mosaic, 1 st century A.D. (Image from Wikimedia commons) Bellerophon was one of the most ancient heroes of Greek mythology and a monster hunter. One day King Iobates gave Bellerophon an impossible quest: to hunt the Chimera, a firebreathing monster. The Chimera was truly ferocious, and Bellerophon could not harm the monster even if he was riding Pegasus, the winged horse. Feeling the heat of the breath of the Chimera, an idea struck
more &raquo; ... m: He got a large block of lead that he mounted on his spear. Then he flew head-on towards the Chimera and managed to lodge the block of lead inside the monster's jaws. The lead melted in the monster's throat and killed the Chimera. Finally Bellerophon returned victorious to King Iobates. Nora Heisterkamp and colleagues in 1983 described the first chimeric, cancer-specific gene, BCR-ABL1, originating from the translocation t(9;22)(q34;11) in chronic myeloid leukemia. Since then many other fusion genes were discovered and found to be primary events in the pathogenesis of different types of cancer. Nowadays the hunt for these chimeras goes on with the help of ever more advanced technologies.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.1002/ijc.31418</a> <a target="_blank" rel="external noopener" href="">pmid:29633253</a> <a target="_blank" rel="external noopener" href="">pmcid:PMC6099316</a> <a target="_blank" rel="external noopener" href="">fatcat:2zqqkcebavd2pi3gen5be3vneu</a> </span>
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