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Isolated monocytosis was the flag preceding abnormalities in other parameters of complete blood counts in chronic myeloid leukemia with e1a2 (minor, P190) BCR-ABL1 chimeric transcripts
2019
Precision and Future Medicine
Chronicmyeloidleukemia(CML)isamyeloproliferativeneoplasmwiththemolecular hallmarkofBCR-ABL1 chimerictranscriptsfromt(9;22)(q24;q22).Inmorethan95%of CML,thefusionoccursinthemajorbreakpointclusterregion(M-bcr)ofBCR,mostcom-monlyproducingthee14a2ore13a2type.CMLwithe1a2BCR-ABL1byfusioninminor bcrisrare,accountingforapproximately1%ofCML.CMLwithe1a2BCR-ABL1isreportedlyassociatedwithmonocytosisandpoorprognosis.Herewedescribeawomanwho underwentbonemarrow(BM)studywithanimpressionofchronicmyelomonocytic
doi:10.23838/pfm.2019.00023
fatcat:7vk4thehxncc5efnjylu75ozhm