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Isolated monocytosis was the flag preceding abnormalities in other parameters of complete blood counts in chronic myeloid leukemia with e1a2 (minor, P190) BCR-ABL1 chimeric transcripts

Jae Won Yun, Jung Yoon, Jong Won Kim, Sun-Hee Kim, Chul Won Jung, Hee-Jin Kim
2019 Precision and Future Medicine  

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Chronicmyeloidleukemia(CML)isamyeloproliferativeneoplasmwiththemolecular hallmarkofBCR-ABL1 chimerictranscriptsfromt(9;22)(q24;q22).Inmorethan95%of CML,thefusionoccursinthemajorbreakpointclusterregion(M-bcr)ofBCR,mostcom-monlyproducingthee14a2ore13a2type.CMLwithe1a2BCR-ABL1byfusioninminor bcrisrare,accountingforapproximately1%ofCML.CMLwithe1a2BCR-ABL1isreportedlyassociatedwithmonocytosisandpoorprognosis.Herewedescribeawomanwho underwentbonemarrow(BM)studywithanimpressionofchronicmyelomonocytic
more » ... eukemiabasedonthrombocytosisandprominentmonocytosis.Geneticworkuprevealed,however,t(9;22)ande1a2BCR-ABL1,whichindicatedCMLandexplainedher unusualmonocytosis.Areviewofserialcompletebloodcounts(CBC)beforetheBM studydemonstratedthatisolatedmonocytosisprecededtheabnormalitiesinotherpa-rametersofCBC.Thepatientisonfollow-upwithtyrosinekinaseinhibitor(TKI,dasatinib)medication.Closemonitoringisrequiredduetotheassociationofe1a2BCR-ABL1 withpoorresponsetoTKIandfrequentdiseaseprogression.Timelygeneticworkup anddeterminationoftheprecisetypeofBCR-ABL1transcriptsarecriticalforthediag-nosisandstratificationofthisraresubtypeofCMLwithdistinctgenotype-phenotype correlations.
doi:10.23838/pfm.2019.00023 fatcat:7vk4thehxncc5efnjylu75ozhm
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Jae Won Yun, Jung Yoon, Jong Won Kim, Sun-Hee Kim, Chul Won Jung, Hee-Jin Kim. "Isolated monocytosis was the flag preceding abnormalities in other parameters of complete blood counts in chronic myeloid leukemia with e1a2 (minor, P190) BCR-ABL1 chimeric transcripts." Precision and Future Medicine 3.1 (2019) 30-35