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T emporal lobe epilepsy (TLE) is a disorder of the nervous system due to unprovoked seizures originating from the temporal lobe. The main cause of TLE is neuronal hyperexcitability due to the presence of pathological changes in the temporal lobe of the brain such as neuronal loss, mutation, granule cell dispersion and malformations of cortical development. This editorial discusses important aspects of the pathogenesis underlying TLE.doi:10.17925/enr.2019.14.2.66 fatcat:ovdd5fazbbhtfilefd3jlhynma