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and Purpose: Although there are strong genetic contributions to coronary artery disease, only a few studies have considered heritable influences on stroke. Methods: We investigated the role of genetic factors in stroke using the Twin Registry maintained by the National Academy of Sciences-National Research Council. The registry includes 15,948 male twin pairs born between 1917 and 1927. In 1985, 9,475 twins responded to a mailed questionnaire, which covered vascular risk factors, cardiacdoi:10.1161/01.str.23.2.221 pmid:1561651 fatcat:v4lqhvfsafaidnkchxziyhzxma