Increased arterial stiffness predicts less recovery of left ventricular systolic function after myocardial infarction
Results: After 3 months of KTx, angptl2 levels decreased from 71 ng/mL (IQR: 53-95) to 11 ng/mL (IQR: 9-15) P<0.001). In multivariate analysis, age, CVD, lower renal function and mean blood pressure were independently associated with higher angptl2 levels. There was a positive relationship between cf-PWV and angptl2 after KTx (rZ0.260 PZ0.024). After a median follow-up of 89 months, 13 deaths occurred. The group with higher angptl2 levels had a higher mortality rate (HRZ 0.249 95% CI:
... 9 95% CI: 0.068-0.912, PZ0.036). Conclusion: There is a significant reduction in serum angptl2 levels after KTx however, our data demonstrate that after KTx, there is a positive association between angptl2, aortic stiffness and mortality, suggesting that angptl2 may play a biological role in CKD-related CVD. Objective: Twenty-four-hour blood pressure variability (BPV) predicts cardiovascular complications in hypertension, but its association with pulse wave indices (central arterial systolic pressure or CASP, pulse wave velocity or PWV, and augmentation index or AIx) is poorly understood. In the present study we assessed the degree of the impact of 24-hour BPV on 24-hour pulse wave indices. Methods: Brachial BP was measured non-invasively over the 24-hours by an electronic, oscillometric, automated device (BPLab) in 661 uncomplicated, treated or untreated, hypertensive patients. Digitalized oscillometric waveforms were analyzed by a validated algorithm in order to obtain pulse wave indices. Twenty-four-hour BPV was calculated as unweighted (SDu) or weighted standard deviation (SDw) of the mean blood pressure, or as average real variability (ARV). Patients were classified in two groups according to whether the 24-hour BPV was below or above the median of the whole group. Results: Twenty-four-hour systolic blood pressure variability (SBPV) showed a direct and significant relation with CASP (rZ0.28 SDu, rZ0.40 SDw, rZ0.34 ARV), aortic PWV (rZ0.10 SDu, rZ0.21 SDw, rZ0.19 ARV) and AIx (rZ0.17 SDu, rZ0.27 SDw, rZ0.23 ARV). After adjustment for age, gender, body mass index, antihypertensive treatment and 24-hour SBP, the relationship was attenuated, but was still significant for all measures, X for AIx. Pulse wave indices were larger in patients with high than in those with low BPV: after adjustment these differences were abolished for AIx. Diastolic BPV showed a weak association with pulse wave indices. Conclusions: In hypertensive patients 24-hour SBPV is moderately and independently associated with 24-hour CASP, wave reflection and stiffness. HYALURONAN IS ASSOCIATED WITH AORTIC STIFFENING IN HEALTHY SUBJECTS Background: Over-expression of hyaluronan (HA), glycosaminoglycan found in the extracellular matrix, results in the stiffening of the arterial wall by thinning of elastic lamellae in animal models. However, the effect in human arteries is more contentious. We aimed to study the relationship between serum HA and aortic stiffness in a cohort of healthy subjects. Methods: Subjects were randomly selected from the Anglo-Cardiff Collaborative Trial (ACCT) database. Subjects underwent detailed haemodynamic assessment, including measurements of blood pressure (BP) and aortic pulse wave velocity (aPWV) (SphygmoCor, AtCor, Australia). Serum HA levels were measured by commercially available ELISA kit (DY3614, R&D Systems, U.K).