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A polymorphic variant of the insulin-like growth factor 1 (IGF-1) receptor correlates with male longevity in the Italian population: a genetic study and evaluation of circulating IGF-1 from the "Treviso Longeva (TRELONG)" study
2009
BMC Geriatrics
Background. An attenuation of the insulin-like growth factor 1 (IGF-1) signaling has been associated with elongation of the lifespan in simple metazoan organisms and in rodents. In humans, IGF-1 level has an age-related modulation with a lower concentration in the elderly, depending on hormonal and genetic factors affecting the IGF-1 receptor gene (IGF-1R). Methods. In an elderly population from Northeastern Italy (n=668 subjects, age range 70-106 years) we investigated the IGF-1R polymorphism
doi:10.1186/1471-2318-9-19
pmid:19460140
pmcid:PMC2692840
fatcat:m64aim6m5ne7jocpopgtf5szdu