Pediatric Neuromyelitis Optica Spectrum Disorder: Case Series and Literature Review

Michela Ada Noris Ferilli, Roberto Paparella, Ilaria Morandini, Laura Papetti, Lorenzo Figà Talamanca, Claudia Ruscitto, Fabiana Ursitti, Romina Moavero, Giorgia Sforza, Samuela Tarantino, Martina Proietti Checchi, Federico Vigevano (+1 others)
2021 Life  
Neuromyelitis Optica Spectrum Disorder (NMOSD) is a central nervous system (CNS) inflammatory demyelinating disease characterized by recurrent inflammatory events that primarily involve optic nerves and the spinal cord, but also affect other regions of the CNS, including hypothalamus, area postrema and periaqueductal gray matter. The aquaporin-4 antibody (AQP4-IgG) is specific for NMOSD. Recently, myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) have been found in a group of AQP4-IgG
more » ... ative patients. NMOSD is rare among children and adolescents, but early diagnosis is important to start adequate therapy. In this report, we present cases of seven pediatric patients with NMOSD and we review the clinical and neuroimaging characteristics, diagnosis, and treatment of NMOSD in children.
doi:10.3390/life12010019 pmid:35054412 pmcid:PMC8779266 fatcat:zuwkdpl5ivg7dajbaty74atrfm