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Cell-surface phosphatidylserine regulates osteoclast precursor fusion
Journal of Biological Chemistry
Edited by Xiao-Fan Wang Bone-resorbing multinucleated osteoclasts that play a central role in the maintenance and repair of our bones are formed from bone marrow myeloid progenitor cells by a complex differentiation process that culminates in fusion of mononuclear osteoclast precursors. In this study, we uncoupled the cell fusion step from both pre-fusion stages of osteoclastogenic differentiation and the post-fusion expansion of the nascent fusion connections. We accumulated ready-to-fusedoi:10.1074/jbc.m117.809681 pmid:29101233 fatcat:vacpvuqt3rfn5put5ovhrvg4ee